复发性血栓形成和第一个上肢静脉血栓形成后的生存率
L E Flinterman1, A van Hylckama Vlieg, F R Rosendaal
1Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Circulation
|September 10, 2008
概括
第一次上肢静脉血栓形成 (UEVT) 具有很高的复发风险,特别是在女性和BMI超过25的人群中. 患有UEVT的患者面临降低的生存率.
科学领域:
- 心血管医学 心血管医学
- 血液学 血液学 血液学
- 血栓形成的研究研究
背景情况:
- 对于第一个上肢静脉血栓形成 (UEVT) 后的结果的有限理解.
- 需要有关UEVT患者发病率,存活率和复发风险因素的数据.
研究的目的:
- 调查第一个UEVT后的发病率,存活率和复发风险因素.
- 评估经历UEVT的患者的长期预后.
主要方法:
- 对224名第一次UEVT患者 (18-70岁) 的前性随访研究.
- 通过抗凝血诊所,国家死亡登记,医疗记录和问卷收集数据.
- 平均随访时间为3年.
主要成果:
- 在3年内,复发的高发病率 (每1000人年43.2人).
- 显著降低生存率:死亡率比一般人群高5.4倍.
- 在女性 (HR 1.8) 和BMI>=25 kg/m2的患者中观察到复发风险增加.
- 在初始血栓形成时使用中央静脉导管与降低复发风险有关.
- 非关节血栓增加了复发风险;前血栓突变没有.
结论:
- 第一次UEVT与糟糕的生命预后和高复发风险有关.
- 复发的主要危险因素包括女性性别,高BMI和非关节血栓.
- 进一步的研究可能会为UEVT的有针对性的预防和管理策略提供信息.
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