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FBXW7针对mTOR进行降解,并与PTEN合作抑制瘤

Jian-Hua Mao1, Il-Jin Kim, Di Wu

  • 1Cancer Research Institute, University of California at San Francisco, 2340 Sutter Street, San Francisco, CA 94143, USA.

Science (New York, N.Y.)
|September 13, 2008
PubMed
概括

瘤抑制剂FBXW7针对哺乳动物的拉帕素 (mTOR) 向降解. 癌细胞中FBXW7的丧失表明对mTOR通路抑制剂 (如拉巴胺) 的敏感性.

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