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Isolation of Epithelial Cells from Human Dental Follicle
Published on: November 5, 2021
脊椎动物口腔牙的双层上皮原点
Vladimír Soukup1, Hans-Henning Epperlein, Ivan Horácek
1Department of Zoology, Charles University in Prague, Vinicna 7, 128 44 Prague, Czech Republic.
Nature
|September 17, 2008
概括
阿克索洛特的研究表明,口腔牙可以从外皮和内皮形成,这挑战了以前的理论. 这表明神经细胞在牙进化中起着关键作用,不论其表皮起源如何.
科学领域:
- 发育生物学 发展生物学
- 进化生物学 进化生物学
- 脊椎动物古生物学 脊椎动物古生物学
背景情况:
- 脊椎动物的口腔通常是由外皮内形成的.
- 传统上,人们认为口腔牙仅来源于外皮 (乳) 和神经介质 (牙,纸).
- 牙的起源,延伸到口腔之外,仍然不清楚,潜在的外皮或内皮来源.
研究的目的:
- 研究脊椎动物口腔牙的胚胎起源,特别是检查外皮和内皮贡献.
- 为了澄清口腔大膜分解后细胞的发育潜力.
- 了解牙发育的进化影响,重点关注神经细胞的作用.
主要方法:
- 利用转基因虫进行详细的命运测绘研究.
- 采用了实验方法的组合,在牙发育过程中追踪细胞系.
- 分析了口腔牙的胚胎来源,包括牙上皮质,牙和牙肉.
主要成果:
- 提供了证据,证明阿克索洛特口腔牙可以从外皮和内皮中衍生出来.
- 证明了混合外皮/内皮来源的牙的存在.
- 观察到口腔牙的发育均性,尽管质表皮的胚胎起源不同.
结论:
- 神经介质似乎在牙启动中发挥了主导作用,超过了上皮质起源.
- 神经细胞的牙生成能力是牙进化中的关键因素.
- 牙的进化可能是由神经的能力驱动的,无论表皮来源如何 ("外在"与"内在").
相关概念视频
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The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
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The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
