尿路双甲度与成年人的医学疾病和实验室异常的关联
Iain A Lang1, Tamara S Galloway, Alan Scarlett
1Epidemiology and Public Health Group, Peninsula Medical School, Barrack Rd, Exeter EX2 5DW, UK.
JAMA
|September 19, 2008
概括
尿液中较高的双甲 (BPA) 含量与成人心血管疾病和糖尿病风险增加有关. 这种常见的化学物质暴露可能导致一般人群中可预防的健康问题.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 双A (BPA) 是一种无处不在的化学物质,存在于用于食品和饮料容器的环氧树脂中.
- 动物研究表明有害影响,引发了人们对慢性低水平暴露的担忧.
研究的目的:
- 研究尿液BPA度与美国成年人的健康状况之间的关联.
- 确定BPA暴露与慢性疾病和代谢标志物之间的潜在联系.
主要方法:
- 从2003-2004年国家健康和营养检查调查中对1455名成年人 (18-74岁) 的横截面分析.
- 测量了尿液中的BPA和肌氨酸度,并根据多种人口和健康因素调整了回归模型.
- 评估了与慢性疾病诊断的关联以及肝功能,葡萄糖平衡,炎症和脂质的血液标志物.
主要成果:
- 尿液BPA度升高与心血管诊断有显著的相关性 (OR=1.39,P=.001).
- 更高的BPA水平也与患糖尿病的可能性更高有关 (OR=1.39,P<.001).
- 观察到与肝酶水平异常的相关性:胺转移酶 (OR=1.29,P<.001) 和性酸酶 (OR=1.48,P=.002).
结论:
- 增加的BPA暴露,表明尿液BPA水平较高,可能与成年人群中可预防的发病率有关.
- 研究结果表明,BPA对慢性疾病的发展可能会对公众健康产生影响.
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