双上大动脉的成年人的结局
Nikolaos Tzemos1, Judith Therrien, James Yip
1Peter Munk Cardiac Centre and Toronto Congenital Cardiac Centre for Adults, University Health Network, University of Toronto, Toronto, Ontario, Canada.
JAMA
|September 19, 2008
概括
双主动脉的成年人面临心脏事件,年龄和门状况是关键预测因素. 然而,在9年的随访期间,生存率与一般人群相比仍然相当.
科学领域:
- 心脏病学 心脏病学
- 遗传性心脏病是一种先天性心脏病.
- 大动脉膜疾病 大动脉膜疾病
背景情况:
- 双动脉 (BAV) 是成年人中最常见的先天性心脏异常.
- 在BAV患者当代的心脏结果需要系统评估.
研究的目的:
- 为了确定心脏结果的频率和预测因素在一个大队列的成年人与BAV.
- 评估当代BAV人群中的长期心脏事件率和存活率.
主要方法:
- 一项队列研究追踪了642名连续的门诊成人患有BAV,平均为9年.
- 多变量分析确定了主要心脏事件的预测因素,包括心脏死亡,大动脉干预,剖析,动脉瘤和心力衰竭.
- 死亡率与年龄和性别匹配的一般人口估计值进行了比较.
主要成果:
- 主要心脏事件发生在25%的患者中,大动脉/上升大动脉干预最常见 (22%).
- 心脏事件的独立预测因素包括30岁以上的年龄,中度/严重的大动脉狭窄,中度/严重的大动脉吐.
- 10年生存率为96%,与一般人群没有显著差异.
结论:
- 年龄,大动脉狭窄的严重程度和大动脉反的严重程度是BAV.成人心脏事件的独立预测因素.
- 尽管可能发生心脏事件,但患有BAV的年轻成年人的长期存活率与一般人群相比较.
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