识别一种利波金,一种脂质激素,将脂肪组织与全身代谢联系起来
Haiming Cao1, Kristin Gerhold, Jared R Mayers
1Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Cell
|September 23, 2008
概括
改变脂肪组织脂质代谢影响全身胰岛素和葡萄糖调节. 研究人员确定了棕酸盐作为一种从脂肪中获得的关键脂蛋白,可以改善胰岛素敏感性并减少肝脏脂肪.
科学领域:
- 代谢研究的研究.
- 内分泌学 在内分泌学.
- 利皮多米克 (Lipidomics) 是一种消化剂.
背景情况:
- 组织中的脂质代谢失调会破坏系统性胰岛素和葡萄糖平衡.
- 脂肪组织在代谢信号传递中起着至关重要的作用.
- 了解脂肪组织的作用是代谢健康的关键.
研究的目的:
- 通过脂质信号调查脂肪组织代谢变化与全身代谢之间的联系.
- 为了确定参与器官间沟通的特定脂质介质.
- 探索脂肪组织脂质伴侣 (aP2和mal1) 在代谢调节中的功能.
主要方法:
- 在小鼠中的定量脂质组学分析.
- 使用缺乏脂肪组织脂质陪伴者aP2和mal1.1的转基因小鼠.
- 系统性脂质分析以识别信号分子.
主要成果:
- 缺乏aP2和mal1的小鼠在脂肪组织中表现出增加的de novo脂质生成,从而产生对食脂质过载的抵抗力.
- 棕酸盐 (C16:1n7) 被确定为一种脂肪组织衍生的脂蛋白.
- 棕酸盐显著增强了胰岛素在肌肉中的作用,并减少了肝脏肥胖症.
结论:
- 脂肪组织通过脂质介导的内分泌网络与遥远的器官进行通信.
- 利波金,如棕酸盐,是系统代谢平衡的关键调节者.
- 准脂肪组织衍生的脂可以为代谢障碍提供治疗策略.
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