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Updated: Jun 23, 2026

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作为活性化化通道子单元的TMEM16A的表达克隆

Björn Christian Schroeder1, Tong Cheng, Yuh Nung Jan

  • 1Department of Physiology, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA.

Cell
|September 23, 2008
PubMed
概括

研究人员将TMEM16A确定为Xenopus卵细胞中的激活化通道 (CaCC). 这一发现促进了对离子通道功能的理解,并为诸如囊性纤维化等疾病提供了潜在的治疗方法.

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Integral membrane proteins are proteins adhered to the lipid bilayer of a cell organelle or membrane. They can be of two types: transmembrane integral proteins that span the lipid bilayer and monotopic proteins that are attached to either side of the membrane but do not pass through it.
Integral transmembrane proteins possess transmembrane and extra membrane domains. The transmembrane domains are primarily made of 20-25 hydrophobic amino acids arranged in a helical secondary confirmation. These...