鼻炎和喘发作:一个基于人口的纵向研究
Rafea Shaaban1, Mahmoud Zureik, David Soussan
1Unit 700 Epidemiology, National Institute of Health and Medical Research (INSERM), Paris, France.
Lancet (London, England)
|September 23, 2008
概括
鼻炎,特别是过敏性鼻炎,显著增加患成人发作喘的风险. 即使是非过敏性鼻炎也能预测喘,这凸显了治疗鼻炎对于呼吸系统健康的重要性.
科学领域:
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
- 肺部病理学 肺部病理学
背景情况:
- 喘和过敏性鼻炎有着已知的联系,但这种关系的确切性质需要进一步阐明.
- 以前的流行病学和临床研究表明,这两种疾病之间存在强烈联系.
- 欧洲共同体呼吸系统健康调查 (ECRHS) 提供了纵向数据来调查这种联系.
研究的目的:
- 为了研究患有过敏性鼻炎和没有过敏性鼻炎的个体的喘发作.
- 为了确定鼻炎,有或没有亚托皮,预测成人发作的喘的发展.
- 在8.8年的随访期内分析发生喘的风险.
主要方法:
- 一项基于人口的纵向研究,涉及6461名20至44岁的参与者,遍布14个欧洲国家的29个中心.
- 参与者在基线被分为四组:对照组,仅亚托皮,非过敏性鼻炎和过敏性鼻炎.
- 考克斯的比例危险模型被用来评估喘发作的调整相对风险.
主要成果:
- 8.8年的喘累积发病率为2.2%,在四个基线组中观察到显著差异 (p<0.0001).
- 在多种因素调整后,非过敏性鼻炎 (RR 2.71) 和过敏性鼻炎 (RR 3.53) 与喘风险增加有显著关联.
- 特别与虫敏感性相关的过敏性鼻炎独立预测了喘风险 (RR 2.79).
结论:
- 鼻炎是成年期喘的强有力的预测因素,不论是亚托皮状态.
- 鼻炎的存在,即使没有过敏,也是晚年患喘的重要危险因素.
- 这些发现强调了管理鼻炎对于预防喘的重要性.
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