转移性心肌菌株的变化:在 mitrale regurgitation 中左心室功能障碍的早期标志物?
Carl J Carlhäll1, Tom C Nguyen, Akinobu Itoh
1Department of Cardiothoracic Surgery, Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, CA 94305-5247, USA.
Circulation
|October 10, 2008
概括
左心室 (LV) 转移性心肌应变的变化可能表明在严重的额叶回 (MR) 中早期的LV功能障碍. 这项研究在一只绵羊模型中发现了菌株变异,这表明了手术时间的潜在新标志物.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 动物模型 动物模型
背景情况:
- 严重的隔离性 mitrale 吐 (MR) 可以导致左心室 (LV) 功能障碍.
- 早期发现LV功能障碍对于无症状患者的及时手术干预至关重要.
- 当前标记器可能无法充分捕捉早期的功能变化.
研究的目的:
- 为了调查LV转移性心肌菌株的变化是否可以在慢性MR模型中作为LV功能障碍的早期标志物.
- 为了将菌株变化与BNP,PRSW和tau等既有标志物进行比较.
主要方法:
- 通过诱导后部 mitra 叶片穿孔,创建了一种慢性纯MR的绵羊模型.
- 在外科手术后1周和12周,使用放射性插入LV壁的珠子组测量了3D跨壁菌株.
- 通过LV质量,LVEDVI,BNP,PRSW和tau来评估LV重塑和功能.
主要成果:
- 与对照组相比,MR模型在12周后显示LV质量和LVEDVI增加.
- 两组之间BNP,PRSW或tau的变化没有显著差异.
- 在12周后,在MR组的下心脏中检测到纵向透静填充菌株的显著变化.
结论:
- 慢性纯MR诱导LV重塑和早期的功能变化,可以通过跨壁肌肉菌株检测到.
- 在这个模型中,跨壁肌心筋应变变似乎是LV功能障碍的更敏感的早期指标,而不是BNP,PRSW或tau.
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