激活通道有助于在心性停止后导致人体冠状动脉微血管功能障碍
Jun Feng1, Yuhong Liu, Richard T Clements
1Division of Cardiothoracic Surgery, BIDMC, LMOB 2A, 110 Francis Street, Boston, MA 02215, USA.
Circulation
|October 10, 2008
概括
心脏停止通过影响激活通道 (K(Ca)) 损害冠状动脉微血管功能. 具体来说,小和中间导电性K ((Ca)) 通道 (SK ((Ca) /IK ((Ca)) 在心脏手术后显示功能减弱.
科学领域:
- 心血管生理学心血管生理学
- 血管生物学 血管生物学
- 手术研究的研究.
背景情况:
- 带有心性心脏骤停 (CP) 的心肺旁路可以导致冠状动脉微血管功能障碍.
- 激活 (K(Ca)) 通道参与调节血管度和功能.
研究的目的:
- 调查K(Ca) 通道在CP和再输血后人类冠状动脉微血管功能障碍中的作用.
- 为了确定参与后CP微血管损伤的K(Ca) 通道的特定亚型.
主要方法:
- 在CP之前和之后收集了人类心房组织.
- 在体外加压动脉放松试验中,使用K(Ca) 通道调节器和血管扩展器进行了测试.
- 通过RT-PCR,免疫斑块和免疫光分析了K(Ca) 通道基因产品的表达.
主要成果:
- 在CP后的再输液显著降低了SK(Ca) /IK(Ca) 通道激活剂 (NS309) 和依赖内皮的血管扩展剂的放松.
- 对大导电性K ((Ca)) 通道 (BK ((Ca)) 激活剂 (NS1619) 和酸的放松保持不变.
- 内皮脱皮消除了对NS309和内皮依赖剂的放松,但不是对NS1619或酸.
- 在CP后,K(Ca) 通道聚和IK(Ca) mRNA水平没有变化.
结论:
- 在CP之后的再注射导致冠状动脉微血管功能障碍.
- 这种功能障碍的SK(Ca) 和IK(Ca) 通道的功能受损,对这种功能障碍有很大影响.
- 这些发现揭示了心脏手术后内皮和光滑肌肉微血管功能障碍背后的新机制.
相关概念视频
Voltage-gated Ion Channels
11.2K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
11.2K
G-Protein Gated Ion Channels
5.4K
GPCRs are primarily responsible for our sense of smell, taste, and vision. The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
Sensory...
5.4K
Antihypertensive Drugs: Action of Calcium Channel Blockers
2.4K
Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
2.4K


