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Updated: Jun 29, 2026

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
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使用激光脱/电离质谱法对金纳米颗粒的细胞吸收进行多重选

Zheng-Jiang Zhu1, Partha S Ghosh, Oscar R Miranda

  • 1Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.

Journal of the American Chemical Society
|October 2, 2008
PubMed
概括

我们开发了一种质谱法,用于测量细胞吸收黄金纳米粒子 (AuNP). 这种技术精确地量化了表面修饰如何影响细胞输送,推动了纳米粒子药物输送研究.

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Immunogold Electron Microscopy01:20

Immunogold Electron Microscopy

Immunoelectron microscopy utilizes immunogold labeling of endogenous proteins with specific antibodies to detect and localize these proteins in cells and tissues. The procedure provides insights into the distribution and quantification of protein under different stimulation conditions offering clues about their functions. Conjugating highly electron-dense gold particles with primary or secondary antibodies allow antigen detection on and within cells, with high resolution and specificity.