相关实验视频
5α-减少酶抑制与部骨折风险之间的关联
Steven J Jacobsen1, T Craig Cheetham, Reina Haque
1Department of Research and Evaluation, Kaiser Permanente Southern California, 100 S Los Robles Ave, Second Floor, Pasadena, CA 91101, USA. steven.j.jacobsen@kp.org
JAMA
|October 9, 2008
概括
长期使用5-α减小酶抑制剂治疗良性前列腺增生 (BPH) 并没有与较高的关节骨折风险有关. 需要进一步的研究来证实这些发现,并调查α-阻断剂的作用.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 老年病的医生 老年病的医生
- 药理学 药理学是指药理学的学科.
背景情况:
- 5α减少酶抑制剂广泛用于良性前列腺增生 (BPH).
- 对骨代谢和骨折风险的长期影响尚不清楚.
- 以前的短期研究显示,对骨代谢没有影响.
研究的目的:
- 调查BPH和关节骨折发生率使用5α减少酶抑制剂之间的关联.
- 评估BPH治疗的男性骨健康的长期安全数据.
主要方法:
- 基于人口的病例控制研究,利用来自南加州凯泽永久医院的数据.
- 包括7076名45岁或以上的男性,发生关节骨折 (病例) 和7076名没有骨折的匹配对照.
- 从1991年开始,电子健康记录被用来识别芬胺的暴露.
主要成果:
- 在暴露于5-α减少酶抑制剂和增加关节骨折风险 (OR,0.77;P = .04) 之间没有发现显著的关联.
- 没有观察到剂量与反应的关系,随着暴露的第三次增加.
- 与对照组相比,在关节骨折病例中,阿尔法阻断剂使用量略有增加 (P = .04).
结论:
- 暴露于5α减小酶抑制剂似乎不会增加患有BPH的男性关节骨折的风险.
- 观察到使用5α-减少酶抑制剂的风险降低和使用α-抑制剂的风险增加需要进一步调查.
- 建议对这些发现进行复制,以确认观察到的关联.
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