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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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相关实验视频

Updated: Jun 29, 2026

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
15:33

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

CTLA-4对Foxp3+调节性T细胞功能的控制

Kajsa Wing1, Yasushi Onishi, Paz Prieto-Martin

  • 1Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

Science (New York, N.Y.)
|October 11, 2008
PubMed
概括

细胞毒性T淋巴细胞抗原4 (CTLA-4) 对于调节性T细胞 (Treg) 功能至关重要. 它缺乏Tregs会导致自身免疫性疾病,并通过影响抗原呈现细胞来增强抗瘤免疫力.

科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 这是一种自身免疫力.

背景情况:

  • 调节Foxp3+CD4+T细胞 (Tregs) 对于免疫耐受性和恒温至关重要.
  • 细胞毒性T淋巴细胞抗原4 (CTLA-4) 在T细胞调节中发挥作用.

研究的目的:

  • 为了研究CTLA-4的功能,特别是在Tregs.
  • 为了确定特异性Treg-CTLA-4缺乏对免疫反应的影响.

主要方法:

  • 在Tregs中使用了一种具有CTLA-4特异性缺陷的小鼠模型.
  • 在体外和体内评估的Treg抑制功能.
  • 分析了免疫细胞种群,自身抗体和瘤免疫.

主要成果:

  • 在小鼠中,特异于Treg的CTLA-4缺乏导致淋巴增殖和致命的自身免疫性疾病.
  • 这种缺陷也导致了强大的抗瘤免疫力.
  • 观察到受损的Treg抑制功能,特别是在树突细胞上降低CD80/CD86的调节.

结论:

  • CTLA-4对于自然Tregs的抑制功能至关重要.

更多相关视频

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Na&#239;ve CD4+ T Cells Using a TGF-&#946;-containing Protocol
08:20

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

相关实验视频

Last Updated: Jun 29, 2026

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
15:33

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Na&#239;ve CD4+ T Cells Using a TGF-&#946;-containing Protocol
08:20

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

  • Tregs需要CTLA-4来调节抗原呈现细胞的活性,并防止自身免疫.
  • 针对Tregs中的CTLA-4可能为自身免疫性疾病和癌症免疫疗法提供治疗策略.