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相关概念视频

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...

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相关实验视频

Updated: Jun 29, 2026

Triplet Fusion Upconversion Nanocapsule Synthesis
08:36

Triplet Fusion Upconversion Nanocapsule Synthesis

Published on: September 7, 2022

微囊将纳米物种喷射到环境中.

Bruno G De Geest1, Michael J McShane, Jo Demeester

  • 1Department of Pharmaceutics, Utrecht University, The Netherlands.

Journal of the American Chemical Society
|October 14, 2008
PubMed
概括

新的微囊以比扩散速度快800倍的速度喷射纳米粒子. 这些先进的微载体能够在粘性液体中快速运输纳米颗粒,在药物输送和组织工程中具有潜在的用途.

科学领域:

  • 材料科学 材料科学 材料科学
  • 纳米技术 纳米技术
  • 生物医学工程 生物医学工程

背景情况:

  • 布朗运动限制了纳米粒子在流体中的运输.
  • 纳米物种的高效输送对于药物输送和组织工程等应用至关重要.
  • 目前在粘性介质中运输纳米粒子的方法通常是缓慢和低效的.

研究的目的:

  • 报告能够喷射纳米粒子的微囊的开发.
  • 量化这些微囊中纳米粒子在水环境中的喷射速度.
  • 探索这些微囊系统在各种科学领域的潜在应用.

主要方法:

  • 新型微囊的合成和表征.
  • 测量纳米粒子在水中的射出速度的实验设置.
  • 对纳米粒子速度与布朗扩散的比较分析.

主要成果:

  • 微囊成功地将纳米粒子喷射到周围环境中.
  • 喷射出来的纳米粒子的速度大约是它们的布朗扩散率的800倍.
  • 在水性介质中证明了快速纳米粒子转移的可行性.

结论:

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Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control
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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

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Last Updated: Jun 29, 2026

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Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control
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Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control

Published on: February 11, 2018

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

  • 开发的微囊提供了一个加速纳米粒子运输的机制.
  • 这项技术为克服纳米运输中的扩散局限性提供了一个有希望的解决方案.
  • 潜在的应用包括增强的药物输送系统和先进的组织工程支架.