吸烟者的婴儿和早产婴儿的心血管应激过敏反应
Gary Cohen1, Silvano Vella, Heather Jeffery
1Department of Women and Child Health, Neonatal Unit, Karolinska Institute, Elevhemmet H1-02, S-171 76 Stockholm, Sweden. Gary.Cohen@kbh.ki.se
Circulation
|October 15, 2008
概括
过早出生或暴露于母亲吸烟的婴儿表现出高心血管反应,这表明未来心脏问题的潜在早期编程. 这种无声的功能障碍可能会增加患高血压等疾病的风险.
科学领域:
- 围产期健康 围产期健康
- 心血管生理学心血管生理学
- 发展规划是指发展规划.
背景情况:
- 过早分娩,低出生体重和母亲吸烟是重要的产周并发症.
- 这些因素与晚年心血管功能障碍的易感性增加有关.
- 识别心血管功能障碍的早期标志物对于公共卫生至关重要.
研究的目的:
- 为了研究心血管功能障碍的初始"沉默"编程.
- 评估患有围产期不良事件的婴儿的心血管反应.
- 识别心血管风险的早期指标.
主要方法:
- 在三个婴儿组中比较心血管反应:对照组,早产婴儿和吸烟母亲的婴儿.
- 使用了两个常规压力测试:4%的二氧化碳 (CO2) 呼吸和被动的头向上倾斜 (60度).
- 测量血压 (BP) 和心率响应在怀孕后40-42周的睡眠期间.
主要成果:
- 与对照组相比,吸烟者的婴儿对二氧化碳的血压和心率反应更高.
- 过早出生的婴儿有预期的血压,但对CO2没有心率反应.
- 与对照组相比,早产和暴露于烟草的婴儿在抬头倾斜时血压升高3到4倍.
结论:
- 在早产婴儿和吸烟者的婴儿中观察到血管,心脏和血压反应性升高.
- 这些发现支持宫内和产后早期"编程"心血管功能障碍的概念.
- 这种早期的功能障碍可能表现为以后的生活并发症,包括高血压或突然婴儿死亡综合征.
相关概念视频
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...
Pulmonary Cycle: Exhalation
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
Asthma-I: Introduction
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Stimulants
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Psychosexual Stages of Personality: Oral
The oral stage is the initial phase of Sigmund Freud's theory of psychosexual development, occurring from birth to approximately 12 to 18 months. During this period, the infant's mouth serves as the primary source of pleasure, with actions such as sucking, chewing, biting, and drinking playing a crucial role in reducing tension. These activities are essential not only for nourishment but also for the infant's psychological and emotional satisfaction.
Weaning, typically occurring around the age...
Weaning, typically occurring around the age...
Stress Prevention and Stress Management Techniques IV
Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...


