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Updated: Mar 31, 2026

Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach
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基因定位的含义 基因定位的含义

Takumi Takizawa1, Karen J Meaburn, Tom Misteli

  • 1National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Cell
|October 16, 2008
PubMed
概括

基因组在核中组织非随机. 这篇论文探讨了空间基因定位的功能相关性及其与高级真核生物中的基因活动的联系.

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Chromatin Position Affects Gene Expression02:35

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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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