由MRN复合体修复的DNA:打破它使它成为它
1Department of Cell Biology and Genetics, Cancer Genomics Center, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
Cell
|October 16, 2008
概括
像telangiectasia类疾病和Nijmegen断裂综合征中的基因组不稳定性是由Mre11-Rad50-Nbs1复合物的破坏引起的. Mre11的核酶活性对于维持哺乳动物基因组稳定性至关重要.
科学领域:
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- ATAXIA-telangiectasia类疾病和Nijmegen断裂综合征的特征是基因组不稳定性.
- 这种不稳定性与Mre11-Rad50-Nbs1 (MRN) 复合体的缺陷有关,Mre11-Rad50-Nbs1 (MRN) 是DNA修复中的关键参与者.
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The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...