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Updated: Jun 29, 2026

Visualization of DNA Repair Proteins Interaction by Immunofluorescence
07:55

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

Mre11核酶活性在DNA修复和基因组稳定性中起着至关重要的作用,与ATM激活不同

Jeffrey Buis1, Yipin Wu, Yibin Deng

  • 1Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Cell
|October 16, 2008
PubMed
概括

这是Mre11/Rad50/NBS1 (MRN) 综合体.

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DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage Can Stall the Cell Cycle02:36

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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...