相关实验视频
与罗菲可西布相关的心血管事件:APPROVE试验的最终分析
John A Baron1, Robert S Sandler, Robert S Bresalier
1Departments of Medicine, and of Community and Family Medicine, Dartmouth Medical School, Hanover, NH, USA.
Lancet (London, England)
|October 17, 2008
概括
环氧酶-2抑制剂罗菲科西布显著增加了心血管事件,包括心脏病发作和中风. 在停止服用药物后,这种高风险持续了一年.
科学领域:
- 心血管医学 心血管医学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 选择性循环氧化酶-2 (COX-2) 抑制与心血管风险有关.
- 在APPROVe研究中,Rofecoxib最初被评估为预防多菌.
- 这项分析重点关注治疗后的长期心血管结果.
研究的目的:
- 为了评估 APPROVe 研究参与者的长期随访后的心血管结果.
- 为了确定与安慰剂相比,在接受罗菲科克西布治疗的患者中,主要不良心血管事件 (APTC终点) 的发生率.
主要方法:
- 一个多中心,随机化,安慰剂控制,双盲试验,涉及2587名患有结直肠腺瘤病史的患者.
- 在停止治疗后至少1年内对心血管事件 (心肌梗塞,中风,心血管死亡) 的随访.
- 考克斯比例危险回归用于分析终点危险比率.
主要成果:
- 在罗菲科克西布组中共发生了59个APTC终点,而在安慰剂组中只有34个 (HR 1.79,95%CI 1.17-2.73;p=0.006).
- 在停止使用罗菲可克西布后的第一年观察到APTC终点的风险增加,尽管在统计学上没有显著意义.
- 在随访期间,APTC终点的危险率保持一致.
结论:
- 罗菲科西布的使用与较高的重大心血管不良事件发生率有关.
- 与罗菲科克西布相关的心血管风险似乎很早就出现,并在治疗停止后持续长达一年.
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