由皮质神经元直接控制麻的肌肉
Chet T Moritz1, Steve I Perlmutter, Eberhard E Fetz
1Department of Physiology & Biophysics and Washington National Primate Research Center, University of Washington, Seattle, Washington 98195, USA. ctmoritz@u.washington.edu
Nature
|October 17, 2008
概括
研究人员创建了脑机接口,可以绕过脊髓损伤. 这项技术使用大脑信号直接控制肌肉刺激,恢复四肢的运动.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 康复医学 康复医学 康复医学
背景情况:
- 脊髓损伤往往导致,中断神经通路.
- 现有的研究分别探索了用于光标控制的脑计算机接口和用于肌肉激活的功能电刺激.
- 恢复意志运动需要绕过损坏的脊髓通道.
研究的目的:
- 通过非人类灵长类动物的运动皮层活动来证明肌肉刺激的直接控制.
- 研究人工连接在后恢复目标导向运动的潜力.
- 通过利用各种神经控制信号,扩大大脑机接口的实用性.
主要方法:
- 来自运动皮层神经元的活动记录在澳门尼姆斯特里纳子中.
- 这些神经信号被用来直接控制肌肉的功能电刺激.
- 子被训练以产生双向手腕扭矩使用这种大脑机器接口.
主要成果:
- 子成功地通过运动皮层活动直接控制肌肉刺激,恢复暂时的手臂的运动.
- 神经信号有效地控制了功能性刺激,而不考虑先前的运动关联,扩大了潜在的控制来源.
- 该系统能够同时控制多个神经元-肌肉对,从而实现复杂的运动.
结论:
- 皮层神经元和肌肉之间的直接人造连接可以弥补中断的脊柱通路.
- 这种脑机界面方法恢复了四肢运动的意志控制.
- 这些发现为用于治疗的自主神经假肢设备铺平了道路.
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