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Updated: May 3, 2026

Visualization of ATP Synthase Dimers in Mitochondria by Electron Cryo-tomography
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Visualization of ATP Synthase Dimers in Mitochondria by Electron Cryo-tomography

Published on: September 14, 2014

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ATPase SecA和蛋白质转位通道复合物的结构

Jochen Zimmer1, Yunsun Nam, Tom A Rapoport

  • 1Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.

Nature
|October 17, 2008
PubMed
概括

细菌蛋白质分泌的SecA ATPase和SecY复合物相互作用,经历了形状变化. 这项结构研究揭示了SeCA如何与SecY结合,以促进蛋白质在膜上转移.

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Förster Resonance Energy Transfer Mapping: A New Methodology to Elucidate Global Structural Features07:09

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ATP Synthase: Structure01:18

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ATP synthase or ATPase is among the most conserved proteins found in bacteria, mammals, and plants. This enzyme can catalyze a forward reaction in response to the electrochemical gradient, producing ATP from ADP and inorganic phosphate. ATP synthase can also work in a reverse direction by hydrolyzing ATP and generating an electrochemical gradient. Different forms of ATP synthases have evolved special features to meet the specific demands of the cell. Based on their specific feature, ATP...
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Integral membrane proteins are proteins adhered to the lipid bilayer of a cell organelle or membrane. They can be of two types: transmembrane integral proteins that span the lipid bilayer and monotopic proteins that are attached to either side of the membrane but do not pass through it.
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