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Updated: Jun 28, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

螺旋β-乳蛋白酶体抑制剂的结构分析

Michael Groll1, Emily P Balskus, Eric N Jacobsen

  • 1Center for Integrated Protein Science at the Department Chemie, Lehrstuhl für Biochemie, Technische Universität München, Lichtenbergstrasse 4, D-85747 Garching, Germany.

Journal of the American Chemical Society
|October 22, 2008
PubMed
概括

研究人员开发了由 (+) - 乳素激素启发的新型螺旋β-乳蛋白酶体抑制剂. 一种化合物强烈抑制了26S蛋白酶体,而其表皮体则表现出弱活性,为药物设计提供了洞察力.

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