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Updated: Jun 28, 2026

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
10:07

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels

Published on: January 27, 2013

选阻塞器对通道进行选,具有滴滴接口双层阵列阵列

Ruhma Syeda1, Matthew A Holden, William L Hwang

  • 1Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

Journal of the American Chemical Society
|October 28, 2008
PubMed
概括

滴滴接口双层使膜蛋白像离子通道一样自发插入. 这使得基于芯片的新方法能够快速选潜在的通道阻塞器.

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Patch Clamp01:18

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...