人类自然杀手细胞子集为粘膜免疫提供了IL-22的天生的来源
Marina Cella1, Anja Fuchs, William Vermi
1Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Nature
|November 4, 2008
概括
一个新发现的自然杀手 (NK) 细胞子集,称为NK-22细胞,存在于粘膜组织中,分泌特定的细胞因子. 这些NK-22细胞有助于保护粘膜部位并抑制炎症.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 具有天生的免疫力.
背景情况:
- 自然杀手 (NK) 细胞是对天生的免疫力至关重要的淋巴细胞,传统上以向感染或癌细胞而闻名.
- 人类NK细胞表现出功能异质性,其中CD56 (暗) 细胞专门从事细胞毒性,CD56 (明亮) 细胞在淋巴结中分泌干扰素- (IFN-).
- 目前对NK细胞子集的知识主要集中在血液和淋巴细胞组织上,在粘膜免疫中作用不那么明确.
研究的目的:
- 在粘膜相关的淋巴组织中发现的一种新型人类NK细胞子集的特征.
- 为了研究这种新的NK细胞子集的细胞因子分泌特征和功能性质.
- 确定这些NK细胞在粘膜免疫和炎症中的作用.
主要方法:
- 从人类粘膜相关的淋巴状组织 (桃体,皮耶斑块) 中分离和描述NK细胞子集.
- 已识别的NK细胞子集的细胞因子分析 (介质素-22 (IL-22),IL-26,白血病抑制因子).
- 使用IL-23进行体外刺激测定和评估NK细胞分泌的细胞因子对上皮细胞的影响.
- 在小鼠模型中的比较分析和细菌感染期间的检查.
主要成果:
- 在粘膜相关的淋巴组织中识别出一种独特的人类NK细胞子集,称为NK-22细胞.
- NK-22细胞被独特编程,在IL-23刺激时分泌IL-22,IL-26和白血病抑制因子.
- 从NK-22细胞分泌的细胞因子促进上皮细胞的增殖,IL-10的产生,以及抗亡分子的表达.
- NK-22细胞也存在于小鼠粘膜组织中,并且在细菌感染期间在小肠中增加.
结论:
- NK-22细胞代表着粘膜表面的一种特殊的先天免疫细胞群.
- 这些细胞提供了IL-22的关键来源,有助于上皮质屏障功能和宿主防御.
- NK-22细胞在调节炎症和保护粘膜部位免受感染方面发挥作用.
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