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依赖NF1的瘤需要一个含有NF1+/--和c-kit依赖骨髓的微环境

Feng-Chun Yang1, David A Ingram, Shi Chen

  • 1Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Cell
|November 6, 2008
PubMed
概括

神经纤维素瘤1型 (NF1) 瘤生长需要在施万细胞中丧失Nf1基因,在骨髓细胞中出现哈普洛缺陷. 准这些细胞中的c-kit信号抑制了瘤的发展,涉及瘤细胞.

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