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Updated: May 7, 2026

Examination of Thymic Positive and Negative Selection by Flow Cytometry
14:29

Examination of Thymic Positive and Negative Selection by Flow Cytometry

Published on: October 8, 2012

在CD8转基因小鼠中的胸膜选择支持对CD4或CD8血统的承诺的教学模型

E A Robey1, B J Fowlkes, J W Gordon

  • 1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032.

Cell
|January 11, 1991
PubMed
概括

当CD8在早期表达时,胸腺中的积极选择会改善CD8+T细胞的发育. 这表明了一个模型,其中自我MHC识别指导T细胞谱系承诺.

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...