生物活性污染物从一次性实验室塑料制品中漏出来
G Reid McDonald1, Alan L Hudson, Susan M J Dunn
1Department of Pharmacology, University of Alberta, Edmonton, AB T6G 2B7, Canada.
Science (New York, N.Y.)
|November 8, 2008
概括
化学物质从一次性实验室塑料制品中漏,影响蛋白质功能和生物测试结果. 这影响了使用常见实验室用品进行生物研究的可靠性.
科学领域:
- 生物化学 生物化学
- 材料科学 材料科学 材料科学
- 实验室实践 实验室实践
背景情况:
- 在生物研究实验室中,一次性塑料用品是必不可少的.
- 塑料制造涉及用于稳定性和性能的添加剂.
- 一些添加剂,如滑动剂和杀菌剂,具有生物活性.
研究的目的:
- 调查一次性塑料制品中的制造剂的浸出情况.
- 评估浸出剂对蛋白质功能和生物测试的影响.
主要方法:
- 从常见的塑料实验室用品中出各种溶剂的分析.
- 测试浸出物质对蛋白质行为和生物试验结果的影响.
主要成果:
- 制造剂显然会从塑料制品中出缓冲剂,DMSO和甲醇.
- 染后的化学物质显著改变了蛋白质的结构和功能.
- 生物测试结果受到这些污染物的深刻影响.
结论:
- 从一次性塑料制品中出制造剂对研究完整性构成重大风险.
- 这些发现需要重新评估生物研究中一次性塑料用品的使用情况.
- 意识和缓解策略对于可靠的实验结果至关重要.
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