在巩固过程中,协会记忆新皮层代码的自发变化
Kaori Takehara-Nishiuchi1, Bruce L McNaughton
1Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, AZ 85724-5115, USA.
概括
中间前额叶皮层 (mPFC) 在学习后逐渐调节记忆表达. 在mPFC中神经发射在巩固过程中对获得的记忆变得有选择性,这表明在没有持续训练的情况下会发生持久的变化.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 记忆的巩固 记忆的巩固
背景情况:
- 中间前额叶皮层 (mPFC) 在调节记忆表达方面发挥着至关重要的作用.
- 记忆巩固包括随着时间的推移逐渐稳定和重组记忆痕迹.
- 最初,记忆依赖于海马体,然后转移到其他大脑区域.
研究的目的:
- 为了研究记忆巩固期间mPFC的神经活动的变化.
- 为了确定mPFC神经发射是否在学习后对获得的记忆变得有选择性.
- 检查这些变化的时间进程及其对继续培训的依赖性.
主要方法:
- 在老鼠的mPFC中记录神经活动的电生理学记录.
- 涉及配对和不配对刺激关联的行为范式.
- 在记忆获取和巩固阶段对神经发射模式的分析.
主要成果:
- 在mPFC中的神经元群体在获得记忆后,在偶联刺激之间的间隔中表现出持续的活动.
- 在未配对刺激之间的间隔期间观察到神经活动减少.
- 这些选择性发射模式在学习后的几周内逐渐发展,而不管继续有条件训练.
结论:
- 在获得记忆之后,mPFC在其神经代码中经历了逐渐的,持久的变化.
- 这些变化支持了记忆巩固理论,即初始依赖海马体的记忆是由mPFC调节的.
- 在mPFC中观察到的神经选择性是独立于持续训练而发生的,突出了内在的巩固过程.
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