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Updated: Aug 7, 2026

Transnuclear Mice with Pre-defined T Cell Receptor Specificities Against Toxoplasma gondii Obtained Via SCNT
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Published on: September 30, 2010

在非自身免疫小鼠中,抗DNA免疫球蛋白转基因的表达

J Erikson1, M Z Radic, S A Camper

  • 1Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.

Nature
|January 24, 1991
PubMed
概括

在正常小鼠中,针对DNA的自我反应性B细胞在发育过程中被阻止,防止产生有害的抗DNA抗体. 这一发现揭示了自身免疫中B细胞耐受性机制.

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High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

Published on: August 16, 2019

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Hybridoma Technology01:31

Hybridoma Technology

Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...