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Updated: Jun 28, 2026

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins
05:35

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins

Published on: March 3, 2016

周核染色体结合在维持基因组稳定性的作用

Karim Mekhail1, Jan Seebacher, Steven P Gygi

  • 1Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|November 11, 2008
PubMed
概括

内核膜 (INM) 蛋白质通过将它们与核外围连接起来来稳定重复性DNA (rDNA). 这种相互作用对基因组稳定至关重要,独立于传统的rDNA沉默机制.

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A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
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