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与抗血小板药物相比,抗血小板的相对有效性是加速冠状动脉血栓溶解和预防早期再封闭
E J Haskel1, N A Prager, B E Sobel
1Cardiovascular Division, Washington University School of Medicine, St. Louis, MO 63110.
Circulation
|March 1, 1991
概括
再组合希鲁丁有效地抑制血栓,通过组织型等离子体激活剂 (t-PA) 改善冠状动脉血栓溶解,并防止再封闭. 这种抗凝剂作用还减少了持续动脉通透的血小板激活.
科学领域:
- 心血管研究研究心血管研究
- 药理学 药理学 是一个学科.
- 血栓形成和血液静止.
背景情况:
- 迅速和持久的冠状动脉血栓溶解对于最佳结果至关重要.
- 血小板激活和血栓激活与血栓溶解延迟和再封闭有关.
- 血小板和血栓在这些过程中的不同作用需要进一步阐明.
研究的目的:
- 为了研究抑制血小板功能与血栓激素活性对血栓溶解速度和再封闭率的影响.
- 为了比较抗血小板剂 (糖蛋白IIb/IIIa抗剂,阿司匹林) 和抗凝剂 (重组希鲁丁,肝素) 的疗效,当与组织型等离子体激活剂 (t-PA) 结合使用时.
主要方法:
- 有意识的电气诱导冠状动脉血栓症的狗接受了静脉注射的t-PA.
- 辅助治疗包括血小板抑制剂 (糖蛋白IIb/IIIa对抗剂,阿司匹林) 或血栓抑制剂 (重组希鲁丁,肝素).
- 评估了血栓溶解时间和重新封闭发生率.
主要成果:
- 阿司匹林缩短了t-PA的血栓溶解时间;糖蛋白IIb/IIIa对抗剂没有.
- 这两种抗血小板药物都延迟了,但并没有始终地防止重新封闭.
- 再组合希鲁丁显著加快了血栓溶解,并防止了所有狗的重新封闭.
- 氨酸没有改善血栓溶解或防止再封闭.
结论:
- 用复合希鲁丁抑制血栓激素在促进冠状动脉血栓溶解和在t-PA治疗后保持血管通透性方面非常有效.
- 希鲁丁的益处可能源于其抗凝活性和二次降低血小板激活.
- 与仅仅抑制血小板或使用肝素相比,向血素提供了一种优越的策略来改善血小板解血疗法.
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