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Updated: Jun 28, 2026

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions
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蛋白质两极化对于稳定AF-2和helix-2'域在PPAR-gamma的联体结合中至关重要

C G Ji1, J Z H Zhang

  • 1Institute of Theoretical and Computational Chemistry, Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.

Journal of the American Chemical Society
|November 15, 2008
PubMed
概括

蛋白质两极化对于稳定过氧体增殖器激活受体 (PPAR-) 和其与罗西格利塔等激动剂的结合至关重要. 这项研究强调了两极化如何保留必要的键和蛋白质结构,这对生物功能至关重要.

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