与年龄有关的黄斑变性
Hanna R Coleman1, Chi-Chao Chan, Frederick L Ferris
1Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Lancet (London, England)
|November 26, 2008
概括
与年龄相关的黄斑变性 (AMD) 是导致视力丧失的主要原因. 像抗氧化维生素,和拉尼比祖马布注射等治疗方法在控制AMD进展和视力方面表现有前途.
科学领域:
- 眼科医生 眼科 眼科
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 与年龄相关的黄斑变性 (AMD) 是老年人视力受损的主要原因,特别是欧洲血统的人.
- 关键的危险因素包括老年,吸烟以及特定的遗传标记,如补充因子H和LOC387715/HtrA1.1.
- 确切的AMD发病原因尚不清楚,但氧化应激和炎症被怀疑是导致AMD的因素.
研究的目的:
- 审查当前对与年龄相关的黄斑变性 (AMD) 风险因素,病原和治疗选择的理解.
- 突出遗传和环境因素在AMD发展中的作用.
- 讨论AMD新兴的治疗策略.
主要方法:
- 对AMD风险因素的流行病学数据和遗传关联研究的审查.
- 对氧化应激和炎症在AMD病变发生中的作用的分析.
- 对抗氧化剂/补充剂和拉尼比祖马布治疗的临床试验结果的评估.
主要成果:
- 随着年龄的增长和吸烟是AMD的重要危险因素.
- 补充因子H和LOC387715/HtrA1被确定为关键的遗传风险因素.
- 抗氧化维生素和显示,晚期AMD的风险降低~25%.
- 内拉尼比祖马布稳定或改善新血管AMD中的视力.
结论:
- 晚年老化受年龄,吸烟和特定遗传倾向的影响.
- 氧化应激和炎症都与AMD的发病有关.
- 目前的治疗方法,包括营养补充剂和抗VEGF疗法,为AMD管理提供治疗效益.
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