改变的昼夜节律调节了杂交动物和全聚类动物的生长活力
Zhongfu Ni1, Eun-Deok Kim, Misook Ha
1Section of Molecular Cell and Developmental Biology, The University of Texas at Austin, One University Station, A-4800, Austin, Texas 78712, USA.
Nature
|November 26, 2008
概括
昼夜时钟基因的表观遗传变化,如CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) 增强杂交动物和全聚类动物的叶绿素和粉生产,解释了它们的优异生长和活力.
科学领域:
- 植物生物学 植物生物学
- 遗传学 是一个遗传学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 杂交物种和全聚合物种与其母物种相比,表现出增强的活力和尺寸.
- 这种现象的潜在机制,特别是在Arabidopsis allotetraploids中,仍然在很大程度上未知.
- 循环时钟是已知的新陈代谢途径的调节者,有助于植物的整体健康.
研究的目的:
- 调查表观遗传修饰在昼夜钟基因中介混合体和全聚合体增强活力的作用.
- 阐明生物钟基因调节影响代谢途径和生长的分子机制.
主要方法:
- 在阿拉比多普西斯 (Arabidopsis) 种中,对关键的昼夜钟基因 (CCA1,LHY,TOC1,GI) 的表观遗传修饰进行分析.
- 对参与叶绿素和粉代谢的下游点的基因表达分析.
- 使用具有突变或RNA干扰 (RNAi) 的转基因植物,准CCA1和TOC1.1.
主要成果:
- 在白天内对CCA1和LHY的表观遗传抑制诱导了杂交动物和allotetraploids中TOC1,GI和下游代谢基因的表达.
- 与母植物相比,这些植物的叶绿素和粉含量增加.
- 突变或RNAi介导的CCA1抑制增强了下游基因表达和代谢含量,而构成性表达则具有相反的效果.
结论:
- 昼夜钟基因的表观遗传调节,特别是CCA1,是驱动混合体和全聚类动物增强生长活力的关键机制.
- 通过CCA1控制昼夜介导的生理和代谢途径,有助于增加多倍体植物的生物质和健康.
相关概念视频
02:45Biological Clocks and Seasonal Responses
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
02:29Hybrid Zones
Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
02:19Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
02:36Cells Coordinate Growth and Proliferation
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
02:19Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
02:36Cells Coordinate Growth and Proliferation
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...