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Updated: Jun 27, 2026

Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples
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坎普托他类型-托波色酶I-DNA三元复合物的持久性:一个分子动力学研究

Fung-Ming Siu1, Chi-Ming Che

  • 1Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.

Journal of the American Chemical Society
|November 28, 2008
PubMed
概括

坎普托塞辛类似物 (CPT) 向托皮索马酶I (top1) 来对抗癌症. 分子动力学模拟显示,CPT与侧面DNA基对的相互作用预测了三元复合的持久性,有助于药物发现.

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