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Published on: December 14, 2016

PA-824通过细胞内NO释放来杀死不复制的Mycobacterium结核病菌

Ramandeep Singh1, Ujjini Manjunatha, Helena I M Boshoff

  • 1Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.

Science (New York, N.Y.)
|November 29, 2008
PubMed
概括

像PA-824这样的循环胺醇被Rv3547激活成des-nitro代谢物. 这些代谢物产生氧化 (NO),这对于无氧杀死Mycobacterium tuberculosis至关重要.

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