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在DNA上完整的PPAR-gamma-RXR-核受体复合物的结构

Vikas Chandra1, Pengxiang Huang, Yoshitomo Hamuro

  • 1Department of Pharmacology, and Center for Molecular Design, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908-0735, USA.

Nature
|December 2, 2008
PubMed
概括

这项研究揭示了完整的氧酶增殖器激活受体- (PPAR-) 和视网膜X受体-α (RXR-α) 异构体如何结合DNA和连接体. PPAR-gamma连接体结合域与DNA结合域合作,以增强基因调节.

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