人体红细胞中的细胞质水和水化层动态
Andreas M Stadler1, Jan P Embs, Ilya Digel
1ILL, 38042 Grenoble, France.
Journal of the American Chemical Society
|December 5, 2008
概括
大多数人体红细胞水的行为就像大量的水一样,但10%的水表现出较慢的动态. 这种较慢的水与血红蛋白结合,形成了水化层的一部分.
科学领域:
- 生物物理学的生物物理.
- 物理化学 物理化学
- 细胞生物学 细胞生物学
背景情况:
- 细胞内的水动态对于生物功能至关重要.
- 了解细胞内水的行为是理解细胞生理学的关键.
研究的目的:
- 为了研究人类红细胞内水分子的动态.
- 为了区分红细胞内部的大量和受限制的水群.
主要方法:
- 使用了准弹性不连贯中子散射 (QIINS).
- 一系列中子光谱仪被用来覆盖不同的时间尺度.
- 实验是在一个生理温度范围 (290-320K) 进行的.
主要成果:
- 大约90%的红细胞水表现出与散装水相比的转化扩散.
- 显而易见的部分 (约10%) 细胞水显示显著降低动力学.
- 这种缓慢的水分离与血红蛋白的动态结合有关,它约占血红蛋白水化层的一半.
结论:
- 人体红细胞含有不同的水族群,具有不同的流动性.
- 血红蛋白显著影响细胞内部分水的动态.
- 这些发现提供了关于水在红细胞功能和结构中的作用的见解.
相关概念视频
Cytoplasm
88.8K
The cytoplasm consists of organelles and a framework of protein scaffolds called the cytoskeleton suspended in an aqueous solution, the cytosol. The cytosol is a rich broth of water, ions, salts, and various organic molecules.
Protein Folding and Misfolding
The cytoplasm is the location for several cellular processes, including protein synthesis and folding. The aqueous nature of the cytosol promotes protein folding such that the hydrophobic amino acid side chains are buried in the protein...
Protein Folding and Misfolding
The cytoplasm is the location for several cellular processes, including protein synthesis and folding. The aqueous nature of the cytosol promotes protein folding such that the hydrophobic amino acid side chains are buried in the protein...
88.8K
Aldehydes and Ketones with Water: Hydrate Formation
4.8K
An oxygen-based nucleophile, like water, can undergo addition reactions with aldehydes and ketones. The reaction leads to the formation of hydrates, also referred to as 1,1-diols or geminal diols.
The formation of hydrates is a reversible reaction. Hydrate formation is influenced by steric and electronic factors accompanying the alkyl substituents on the carbonyl group: The rate of hydrate formation increases with a decrease in the number of alkyl groups attached to the carbonyl carbon. Hence,...
The formation of hydrates is a reversible reaction. Hydrate formation is influenced by steric and electronic factors accompanying the alkyl substituents on the carbonyl group: The rate of hydrate formation increases with a decrease in the number of alkyl groups attached to the carbonyl carbon. Hence,...
4.8K
Cytoplasm
8.3K
The cytoplasm consists of organelles and a framework of protein scaffolds called the cytoskeleton suspended in an aqueous solution, the cytosol. The cytosol is a rich broth of water, ions, salts, and various organic molecules.
Protein Folding and Misfolding
The cytoplasm is the location for several cellular processes, including protein synthesis and folding. The aqueous nature of the cytosol promotes protein folding such that the hydrophobic amino acid side chains are buried in the protein...
Protein Folding and Misfolding
The cytoplasm is the location for several cellular processes, including protein synthesis and folding. The aqueous nature of the cytosol promotes protein folding such that the hydrophobic amino acid side chains are buried in the protein...
8.3K
Hydration of Cement
915
Hydration of cement is a chemical reaction between cement particles and water. This process occurs primarily through two mechanisms: through-solution and topochemical. In the through-solution process, anhydrous compounds dissolve into their constituents, hydrates form in the solution, and then precipitate from the supersaturated solution. The topochemical process involves solid-state reactions at the cement particle surface. The through-solution process dominates the topochemical process at the...
915
Aqueous Solutions and Heats of Hydration
17.9K
Water and other polar molecules are attracted to ions. The electrostatic attraction between an ion and a molecule with a dipole is called an ion-dipole attraction. These attractions play an important role in the dissolution of ionic compounds in water.
When ionic compounds dissolve in water, the ions in the solid separate and disperse uniformly throughout the solution because water molecules surround and solvate the ions, reducing the strong electrostatic forces between them. This process...
When ionic compounds dissolve in water, the ions in the solid separate and disperse uniformly throughout the solution because water molecules surround and solvate the ions, reducing the strong electrostatic forces between them. This process...
17.9K
Role of Water in Human Biology
13.3K
Water is the one of the most significant components of the human body; it plays a crucial role in several physiological activities because of its unique physicochemical properties. Importantly, it helps to regulate body temperature and is the chief component of several body fluids.
Water's Solvent Properties
Since water is a polar molecule with slightly positive and slightly negative charges, ions and polar molecules can readily dissolve in it. Therefore, it is referred to as a solvent, a...
Water's Solvent Properties
Since water is a polar molecule with slightly positive and slightly negative charges, ions and polar molecules can readily dissolve in it. Therefore, it is referred to as a solvent, a...
13.3K


