泛素-1半通道的激活增加了海马体中异常爆发的可能性

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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Roger J Thompson1, Michael F Jackson, Michelle E Olah

  • 1Department of Psychiatry and Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada. rj.thompson@ucalgary.ca

Science (New York, N.Y.)
|December 6, 2008
PubMed
概括

由N-甲基-d-酸盐受体 (NMDARs) 激活的Pannexin-1 (Px1) 半通道影响神经元信号传递. 阻断Px1减少了NMDAR诱导的电流和形活动,突出了它在发作中的作用.

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