金属模板控制形成的 [11]ane-P2C(NHC) 大循环
Oliver Kaufhold1, Andreas Stasch, Tania Pape
1Institut fur Anorganische and Analytische Chemie, Universitat Munster, Corrensstrausse 36, D-48149 Munster, Germany.
Journal of the American Chemical Society
|December 11, 2008
概括
本研究探讨了使用金属模板辅助反应合成N-异环碳二二氨酸宏循环. 研究人员成功地用和制造了新的宏环复合物,其特点是用X射线晶体学.
科学领域:
- 有机金属化学 有机金属化学
- 协调化学 协调化学
- 合成化学 合成化学
背景情况:
- 由于其独特的结构和电子特性,N-异环碳二二氨酸宏循环具有兴趣.
- 金属模板辅助循环化为构建复杂的宏观循环架构提供了一条途径.
研究的目的:
- 通过金属模板辅助循环化探索N-异环碳二二氨酸宏循环的合成.
- 为了研究与和复合形成的功能化碳和二素联体的反应性.
- 为了描述由此产生的金属复合物和中间体.
主要方法:
- 合成含有NH,NH-功能化碳联体的和复合物.
- 用金属模板辅助的循环反应,涉及具有反应性替代剂的二素联体.
- 核友性攻击和分子内移位反应用于宏循环形成.
- 使用光谱方法 (NMR,IR,质谱) 和X射线晶体学进行表征.
主要成果:
- 成功合成了复合物,包括一个二素四碳化合物 [3] 和一个Re(I) 四碳化合物 [5].
- 通过化物的核友移位,形成碳二二三基中间体 ([H(2) - 6]Cl) 和随后的宏环复合物 ([8]Cl).
- 与复合体观察到类似的化学反应,产生宏环碳二二三乙酸 ([14](+)).
- 对多个关键复合体的X射线晶体结构确定,证实了它们的分子结构.
结论:
- 金属模板辅助循环化是合成N-异环碳二宏循环的有效策略.
- 替代酸联体的反应性对于通过核友性攻击形成宏循环至关重要.
- 该研究提供了一个强大的合成路线和对这些新型有机金属宏循环的结构洞察.
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