从基底细胞的体外投射是伪层化表皮质中的光线传感器
Winnie Wai Chi Shum1, Nicolas Da Silva, Mary McKee
1Center for Systems Biology, Program in Membrane Biology/Nephrology Division, Massachusetts General Hospital, Boston, MA 02114, USA.
Cell
|December 17, 2008
概括
某些组织的基底细胞向光层延伸投射,使它们能够感知环境. 这一发现揭示了上皮细胞沟通和调节组织功能的新机制.
科学领域:
- 细胞生物学 细胞生物学
- 皮质生物学 皮质生物学
- 生殖生物学 生殖生物学
背景情况:
- 基底细胞通常局限于表皮的基底侧.
- 它们与光环境的直接相互作用以前没有被记录下来.
研究的目的:
- 为了研究 pseudostratified 表皮质中基底细胞的亚细胞定位和功能.
- 探索基底细胞投射在感知光环境和调节上皮质功能中的作用.
主要方法:
- 使用高分辨率的3D共聚焦成像来可视化细胞结构.
- 进行了免疫组织化学和受体局部化研究.
主要成果:
- 观察到基底细胞向光层延伸细细的细胞质突出,穿过男性生殖和呼吸道的紧密结节.
- 这些投影被发现含有血管新生素II型2受体 (AGTR2) 在 epididymis.
- 血管新生素II激活光AGTR2刺激了邻近的透明细胞中的质子分泌.
结论:
- 基底细胞可以通过专门的细胞质投射来积极感知光环境.
- 这种相互作用促进基底细胞与其他上皮细胞之间的交叉交流,调节上皮细胞功能.
- 提出了一种新的表皮沟通和调节模式,涉及基底细胞光线传感.
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