在慢性心力衰竭中,在运动期间的CO2输出的呼吸和循环分析
R Hachamovitch1, H V Brown, S A Rubin
1Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Circulation
|August 1, 1991
概括
在慢性心力衰竭 (CHF) 患者中,由于心脏输出不足,运动限制了二氧化碳 (VCO2) 的输出. 这被更大的静脉动脉CO2差异所补偿,这是由动脉CO2减少所驱动的.
科学领域:
- 心脏病学 心脏病学
- 肺部生理学 肺部生理学
- 运动生理学 运动生理学
背景情况:
- 二氧化碳输出 (VCO2) 受循环功能和呼吸的影响.
- 了解VCO2调节在慢性心力衰竭 (CHF) 中至关重要.
研究的目的:
- 为了研究控制VCO2的机制在运动期间的CHF患者.
主要方法:
- 研究了14名患有NYHA三级心脏衰竭的患者.
- 测量血液动力学,通风和静脉/静脉血液气体在静止状态和50W运动期间.
- 使用菲克原理和CO2张力-含量关系分析了VCO2.
主要成果:
- 由于心脏输出有限,CHF患者在运动期间表现出扩大的静脉动脉CO2含量差异.
- 这种扩大是由动脉二氧化碳含量下降引起的,而不是静脉二氧化碳含量增加.
- 运动诱导的代谢酸和低头症有助于降低动脉二氧化碳.
结论:
- 在运动影响VCO2.2期间CHF患者的循环限制.
- 扩大的静脉动脉二氧化碳含量差异可以弥补心脏输出量的减少.
- 动脉缺血症和代谢酸是这种补偿机制的关键因素.
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