吸烟和结直肠癌:一个元分析
Edoardo Botteri1, Simona Iodice, Vincenzo Bagnardi
1Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141, Milano, Italy. edoardo.botteri@ieo.it
JAMA
|December 18, 2008
概括
吸烟显著增加结直肠癌发病率和死亡率的风险. 这一元分析证实了剂量与反应的关系,特别是在吸烟30年后.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 结肠直肠癌是全球癌症死亡的主要原因.
- 以前关于吸烟与结直肠癌的联系的研究结果不一致.
研究的目的:
- 为了澄清吸烟与结直肠癌之间的关联.
- 通过对观察性研究的元分析,分析发病率和死亡率数据.
主要方法:
- 在2008年5月之前,在PubMed,Web of Science和EMBASE进行了全面的文献搜索.
- 数据提取和风险估计由三名调查人员独立进行.
- 在分析中包括了106项关于发病率和17项关于死亡率的研究.
主要成果:
- 吸烟者患结直肠癌的风险增加了1.18 (95% CI,1.11-1.25) 和死亡风险增加了1.25 (95% CI,1.14-1.37).
- 观察到显著的剂量反应关系,风险随着包装年数和每日吸烟量的增加而增加.
- 在吸烟30年后,这种关联在统计学上显著,并且对于直肠癌比结肠癌更强.
结论:
- 吸烟是结直肠癌的重要危险因素.
- 这些发现强调了戒烟对于减少结肠直肠癌负担的重要性.
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