睡眠时间短,以及发生的冠状动脉化
Christopher Ryan King1, Kristen L Knutson, Paul J Rathouz
1Department of Health Studies, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA.
JAMA
|December 26, 2008
概括
测量睡眠时间较长与冠状动脉化发病率较低有关. 即使考虑到各种风险因素和潜在的调解者,这种关联仍然很重要.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 预防性健康 预防性健康
背景情况:
- 冠状动脉化 (CAC) 是亚临床冠状动脉心脏病的关键指标.
- 睡眠时间越来越多地被认为与已确定的CAC风险因素相关.
研究的目的:
- 调查客观和主观睡眠测量与CAC的5年发病率之间的关联.
- 为了确定传统的CAC风险因素是否调解睡眠和CAC发病率之间的关系.
主要方法:
- 这是一项观察性队列研究,对495名年轻人中冠状动脉风险发展研究 (CARDIA) 的中年健康成年人进行观察.
- 客观睡眠时间和碎片化被用手腕动图测量.
- 在基线和5年随访期间,通过计算机断层扫描评估了CAC.
主要成果:
- 在5年内,观察到新的CAC发病率为12.3%.
- 测量睡眠时间较长与CAC发病率降低显著相关 (aOR为每小时0.67,P=0.01).
- 没有发现传统的CAC风险因素具有显著的调解作用.
结论:
- 较长的睡眠时间独立地与冠状动脉化发病率较低有关.
- 睡眠时间可能是预防冠心病的一个可改变因素.
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