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相关概念视频

Cell Migration01:09

Cell Migration

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Cell Migration01:19

Cell Migration

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Cell Motility through Blebbing01:16

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Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
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Cytoskeletal Coordination in Cell Migration01:32

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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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相关实验视频

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Measuring Fast Calcium Fluxes in Cardiomyocytes
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Measuring Fast Calcium Fluxes in Cardiomyocytes

Published on: November 29, 2011

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的闪会引导细胞迁移.

Chaoliang Wei1, Xianhua Wang, Min Chen

  • 1Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871, China. chaoliang.wei@gmail.com

Nature
|January 2, 2009
PubMed
概括
此摘要是机器生成的。

细胞迁移依赖于有模式的信号,或"闪",这些信号在细胞前端极化. 这些闪指导方向感应和细胞转向,以应对生长因子.

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科学领域:

  • 细胞生物学 细胞生物学
  • 生物物理学的生物物理.
  • 发展生物学 发展生物学

背景情况:

  • 定向细胞运动对于发育,组织修复和再生至关重要.
  • 离子在细胞迁移中发挥着多方面的作用,影响传感,细胞骨动力学和粘附.
  • 了解信号的空间和时间调节是解读细胞迁移机制的关键.

研究的目的:

  • 为了可视化和描述人类胚胎肺纤维细胞迁移中的高微域 ("闪") 的时空模式.
  • 研究控制闪活动的调节机制,特别是它们与膜张力和化学吸引剂信号的合.
  • 为了确定有组织的闪活动如何影响细胞的方向性和对外部梯度的反应.

主要方法:

  • 活细胞成像可视化迁移纤维细胞中的微域 (闪).
  • 药理和基因操纵,以探测TRPM7和2型伊诺西-1,4,5-三酸盐受体的作用.
  • 应用化疗吸引剂梯度 (血小板衍生生长因子) 来评估定向反应.

主要成果:

  • 高微域 ("闪") 被可视化,并显示在迁移的纤维细胞中具有活跃的模式.
  • 发现闪活动与通过TRPM7通道的膜张力和通过IP3Rs的化学吸引剂信号结合在一起.
  • 闪表现出前后两极化 (4:1) 与全球梯度相反,对于针对外部梯度的细胞转向至关重要.

结论:

  • 微域的时空组织是细胞迁移方向的关键决定因素.
  • 闪,由膜张力和信号通路调节,编排复杂的细胞行为,如指导运动和转动.
  • 这项研究揭示了一种新的机制,即局部动力学控制了组织过程中必不可少的基本细胞行为.