在冠状动脉心脏病中的HDL胆固醇和其他脂质. 合作性脂蛋白表型化研究
Circulation
|May 1, 1977
概括
较低的高密度脂蛋白 (HDL) 胆固醇水平与冠心病 (CHD) 患病率有关. 这种反向关联即使考虑到其他脂质水平,也仍然显著,突出显示了高密度胆固醇 (HDL胆固醇) 的存在.
科学领域:
- 心血管流行病学心血管流行病学
- 脂质代谢 脂质代谢是什么
- 公共卫生 公共卫生
背景情况:
- 冠心病 (CHD) 仍然是全球死亡的主要原因.
- 禁食脂质水平是心血管疾病的确立危险因素.
- 了解不同脂蛋白部分在心血管疾病中的特定作用对于预防策略至关重要.
研究的目的:
- 调查禁食脂质水平与冠状动脉心脏病 (CHD) 的患病率之间的联系.
- 检查不同祖先和地理位置的不同人口之间的这些关联.
主要方法:
- 进行了一项病例控制研究,涉及6859名40岁及以上的男性和女性.
- 参与者来自五个不同的地区:奥尔巴尼,弗雷明汉姆,埃文斯县,霍诺卢卢和旧金山.
- 禁食脂质水平,包括高密度脂蛋白 (HDL) 胆固醇,低密度脂蛋白 (LDL) 胆固醇和甘油三,被评估和比较病例 (有心脏病) 和对照 (没有心脏病).
主要成果:
- 在所有主要研究组中,高密度脂蛋白 (HDL) 胆固醇的平均水平在患有心脏病的人群中与没有心脏病的人群相比始终较低.
- 这种HDL胆固醇和心脏病发病率之间的反向关联在统计学上是显著的,尽管平均差异很小 (3-4 mg/dl).
- 即使调整了低密度脂蛋白 (LDL) 胆固醇和甘油三的水平,反向的高密度胆固醇-心脏病关系仍然存在,而LDL胆固醇,总胆固醇和甘油三与心脏病之间的直接关系在研究组中不那么一致.
结论:
- 较低的高密度脂蛋白 (HDL) 胆固醇水平与冠状动脉心脏病 (CHD) 的患病率增加显著相关.
- 这种反向关系是一个强有力的发现,独立于其他主要的脂质危险因素,如LDL胆固醇和甘油三.
- 在不同的人群中,高密度胆固醇与心脏病的持续反向关联强调了它作为潜在的预防心血管疾病的保护因素的重要性.
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