金字塔神经元的皮层内电路反映了它们的远程轴突目标
Solange P Brown1, Shaul Hestrin
1Department of Comparative Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Edwards Building, R314, Stanford, California 94305-5342, USA.
Nature
|January 20, 2009
概括
局部大脑电路是由神经元连接组织的. 金字塔神经元的连接性反映了它们的远程目标,表明皮质中的专门信息处理流.
科学领域:
- 神经科学是一个神经科学.
- 细胞神经科学 细胞神经科学
- 系统神经科学 系统神经科学
背景情况:
- 皮层柱在不同的流中处理信息.
- 这些流分布在各种皮质和皮质下大脑区域.
- 当地皮层内电路的组织及其与远程投影的关系仍然不完全理解.
研究的目的:
- 调查金字塔神经元之间的局部皮质内连接是否反映了它们的特定远程轴突目标.
- 为了确定皮层内不同的处理流是否反映在局部突触连接的差异.
主要方法:
- 从多达四个反向标记的金字塔神经元同时进行电生理记录.
- 神经元是通过它们的投射目标来识别的:上部结核,逆侧条纹体或逆侧皮质.
- 评估突触连接模式,包括单突触和前连接.
主要成果:
- 突触连接的概率取决于突触前和突触后神经元的功能同一性.
- 与皮质皮层或皮质干细胞神经元相比,皮质干层或皮质干细胞神经元表现出单突触连接的频率显著更高.
- 从皮质皮层神经元到皮质组织神经元的前连接的可能性大大高于任何一组内的连接.
- 观察到的连接概率差异并不能完全由单独的轴突突重叠来解释.
结论:
- 局部金字塔细胞网络的组织反映了这些神经元的特定远程目标.
- 选择性突触相互作用表明在局部皮质电路内存在功能分离.
- 局部网络架构是为支持来自大脑皮层的不同信息处理流量而设计的.
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