内皮原生细胞在慢性试验性血管疾病中恢复功能
Alejandro R Chade1, Xiangyang Zhu, Ronit Lavi
1Division of Nephrology and Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Circulation
|January 21, 2009
概括
内皮原生细胞 (EPC) 通过维护微血管功能和减少重塑来保护脏在血管疾病中. 这种治疗方法在治疗慢性病方面表现有前途.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血管生物学 血管生物学
- 再生医学是一种再生医学.
背景情况:
- 动脉狭窄 (RAS) 通过微血管损伤损害功能.
- 内皮原生细胞 (EPC) 对于新血管化和修复至关重要.
- 这项研究调查了EPC在实验性血管疾病中的保护作用.
研究的目的:
- 为了确定EPC补充是否保护慢性实验性血管疾病中的微循环.
- 评估EPCs对脏血液动力学,功能和微血管改造的影响.
主要方法:
- 在体内评估单个脏的血液动力学和功能使用多检测器计算机断层扫描在猪.
- 通过微型计算机断层扫描,组织学和西式斑点检查,对脏微血管改造和血管性途径进行了ex vivo分析.
- 在有RAS的猪体内注射自身EPCs.
主要成果:
- EPCs增强了血管生成因子的表达,并刺激了新血管的增殖和成熟.
- 在RAS中,EPC治疗减弱了脏微血管改造和纤维化.
- EPCs使脏微血管和过功能受损正常化.
结论:
- 在实验性慢性RAS中,单次静脉内输注EPC可保持微血管架构和功能.
- EPCs可能恢复了血管生成级联,促进血管成熟和稳定.
- 自体EPC代表了一种有前途的疗法,用于在血管疾病中保持功能.
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