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在子头 ribozyme 中探测一般酸催化

Jason M Thomas1, David M Perrin

  • 1Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, B.C., Canada, V6T 1Z1.

Journal of the American Chemical Society
|January 22, 2009
PubMed
概括

双价金属 (M(2+)) 和一个特定的 ribozyme 组对于头 ribozyme 一般酸催化是至关重要的. 这项研究澄清了它们的作用,表明M2+) -辅因子协调降低了G8 2'-OH pKa).

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