相关实验视频
在接受长期血液透析的患者中,液体保留与心血管死亡率有关
Kamyar Kalantar-Zadeh1, Deborah L Regidor, Csaba P Kovesdy
1Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W Carson St, C1-Annex, Torrance, CA 90509-2910, USA. kamkal@ucla.edu
Circulation
|January 28, 2009
概括
血液透析患者的液体保留显著增加了死于所有原因和心血管事件的风险. 管理透析间的体重增加对于改善正在接受治疗的慢性病患者的存活率至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 患有慢性病 (5期) 接受血液透析的患者与心力衰竭患者有相似之处,特别是流体保留和高死亡率.
- 体积过载是心力衰竭患者不良结果的已知预测因素.
研究的目的:
- 调查血液透析患者的透析间液体增加和全因和心血管存活率之间的关联.
- 为了确定更多的水分保留是否与这个人群中较差的生存结果相关.
主要方法:
- 对美国34,107名血液透析患者的2年死亡率数据的分析.
- 分析间体重增加分为0.5公斤的分类,检查2001年7月至2003年6月的体重增加.
- 多变量调整人口统计和营养不良-炎症复合物的替代品.
主要成果:
- 86%的患者经历了超过1.5公斤的透析间体重增加.
- 未经调整的分析显示,更高的体重增加与更好的营养状况和生存率有关.
- 经过多变量调整后,增加体重增加与更高的全因和心血管死亡风险有关.
结论:
- 血液透析疗程之间更大的液体保留与所有原因和心血管死亡率的风险增加有关.
- 在血液透析患者中,水分保留对心血管存活的影响背后的机制可能与心力衰竭患者的机制相似.
- 需要进一步的研究来探索这些机制及其临床影响.
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